2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate - Names and Identifiers
Name | N(alpha)-boc-L-tryptophan hydroxy-succinimide ester
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Synonyms | Boc-Trp-OSu BOC-TRP-OSU Boc-L-Tryptophan N-Hydroxysuccinimide Ester N-ALPHA-BOC-L-TRYPTOPHAN HYDROXYSUCCINIMIDE ESTER N(alpha)-boc-L-tryptophan hydroxy-succinimide ester N-ALPHA-BOC-L-TRYPTOPHAN N-HYDROXYSUCCINIMIDE ESTER -(tert-Butoxycarbonyl)-L-tryptophan N-Succinimidyl Ester Nalpha-Boc-L-tryptophan N-Succinimidyl Ester
Boc-Trp-OSu Nα-(tert-Butoxycarbonyl)-L-tryptophan N-SucciniMidyl Ester 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)tryptophanate 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate N(ALPHA)-(TERT-BUTOXYCARBONYL)-L-TRYPTOPHAN N-HYDROXYSUCCINIMIDE ESTER CarbaMic acid, [(1S)-2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-(1H-indol-3-ylMethyl)-2-oxoethyl]-, 1,1-diMethylethyl ester
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CAS | 3392-11-8
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EINECS | 222-234-4 |
InChI | InChI=1/C20H23N3O6/c1-20(2,3)28-19(27)22-15(18(26)29-23-16(24)8-9-17(23)25)10-12-11-21-14-7-5-4-6-13(12)14/h4-7,11,15,21H,8-10H2,1-3H3,(H,22,27) |
2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate - Physico-chemical Properties
Molecular Formula | C20H23N3O6
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Molar Mass | 401.41 |
Density | 1.35g/cm3 |
Melting Point | 146-148°C |
BRN | 462939 |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
Refractive Index | 1.615 |
MDL | MFCD00022756 |
2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate - Risk and Safety
WGK Germany | 3 |
FLUKA BRAND F CODES | 3-10-21 |
2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate - Introduction
N(alpha)-boc-L-tryptophan hydroxy-succinimide ester is a chemical reagent with the following properties:
Chemical name: N(alpha)-boc-L-tryptophan hydroxy-succinimide ester
Molecular formula: C27H28N4O6
Molecular weight: 508.54g/mol
Appearance: White solid
It is mainly used for the synthesis of peptides and proteins, and has important application value in the field of biochemistry. It can be used in peptide synthesis as an activated amino acid ester and is commonly used as a peptide chain extender or peptide coupling reagent. It can react with free amino groups in amino acids, peptides or proteins to form new peptide bonds. In chemical synthesis, the compound is often used in the synthesis of various bioactive peptides, peptide drugs and peptide nanomaterials.
Its preparation method is generally obtained by the reaction of hydroxysuccinyl chloride and Boc-L-tryptophan. Hydroxysuccinyl chloride is first dissolved in a suitable solvent, then excess Boc-L-tryptophan is added and reacted under appropriate reaction conditions. Finally, the pure product was obtained by extraction and purification.
when using N(alpha)-boc-L-tryptophan hydroxy-succinimide ester should pay attention to safety matters. This compound may be a health hazard and appropriate protective measures should be used, such as wearing gloves and protective glasses. Avoid inhaling its dust or vapors of the solution and should be operated in a well-ventilated laboratory. Avoid contact with skin and eyes, such as inadvertent contact, immediately rinse with plenty of water. Store properly and away from ignition and oxidizing agents.
Last Update:2024-04-09 21:00:56